Experimental Observations and Simulations by Genomic Object Net of Notch Signaling in Drosophila Multicellular Systems
نویسندگان
چکیده
The Delta-Notch signaling system plays an essential role in various morphogenetic systems of multicellular animal development [1]. Here we analyzed the mechanism of Notch-dependent boundary formation in the Drosophila large intestine by experimental manipulation of Delta expression and computational modeling and simulation by Genomic Object Net (GON) [3]. GON is proved to be a useful and flexible biosimulation system that is suitable for analyzing complex biological phenomena such as patternings of multicellular systems as well as intracellular changes in cell states including metabolic activities, gene regulation, and enzyme reactions.
منابع مشابه
Boundary Formation by Notch Signaling in Drosophila Multicellular Systems: Experimental Observations and Gene Network Modeling by Genomic Object Net
The Delta-Notch signaling system plays an essential role in various morphogenetic systems of multicellular animal development. Here we analyzed the mechanism of Notch-dependent boundary formation in the Drosophila large intestine, by experimental manipulation of Delta expression and computational modeling and simulation by Genomic Object Net. Boundary formation representing the situation in nor...
متن کاملXenopus Cell Cycle Pathway for Simulating Cell Division Processes by Genomic Object Net
To establish methods for modeling multicellular systems is the current important issues in biopathway simulations. This paper proposed a new method for modeling cell division processes with using a famous multicellular phenomenon “the changes in cell division cycles from synchronous to asynchronous in Xenopus” and succeeded in simulating this phenomenon with GON. Matsuno et al. [3] modeled and ...
متن کاملSimulated Cell Division Processes of the Xenopus Cell Cycle Pathway by Genomic Object Net
Matsuno et al.[1] modeled and simulated that multicellular patterning by the Drosophila Delta-Notch signaling pathway by using the software "Genomic Object Net" which was developed based on hybrid functional Petri net (HFPN) architecture. In this model, cellular formation is fixed throughout the simulation. This paper constructs an HFPN model of the Xenopus cell cycle pathway, which includes th...
متن کاملGenomic Object Net 1.5: A Platform for Biopathway Modeling and Simulation
In the post-genome era, biopathway information processing is one of the most important issues in bioinformatics. Development of Genomic Object Net [6] is our approach to this issue. This software aims at describing and simulating structurally complex dynamic causal interactions and processes such as metabolic pathways, signal transduction cascades, gene regulations. In Dec/2002, we have release...
متن کاملComparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation
Objective(s): NOTCH signaling pathway is well known for its role in cell fate, cell survival, cell differentiation, and apoptosis. Some of the NOTCH signaling genes are critical for endometrial function and implantation in animals and appear to play a similar role in humans. The purpose of the current study was to investigate the potential roles of some main components of the NOTCH family in hu...
متن کامل